These data were published in:

Nieus T., Di Marco S., Maccione A., Amin H. and Berdondini L., Investigating cell culture dynamics combining high density recordings with dimensional reduction techniques, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2015

Any person downloading these accepts to acknowledge this study by citing it in every publication or report arising from the use of these data. 
Data description:
The data consist of the spiking activity of hippocampal cell cultures recorded with the high density 4096 electrodes MEA device. The following protocol was repeated for each experiment (five different experiments: 331, 332, 208, 212, 214)

1.  spontaneous activity;
2.  basal: stimulation is delivered and activity is recorded;
3. norepinephrine:  stimulation is delivered and activity is recorded;
   For each experiment, the phase of the outlined experimental protocol is reported (e.g. for experiment 331, step 2 corresponds to file Chip331_Phase08_stim_spikes.txt etc...). Refer to the Excel file "Table of Experiments batch 3.xlsx" for further details about experiments 331 and 332 and refer to “Experiments batch 4.txt” for further details about experiments 208, 212, 214.
   File format:
   Each file (filename_spikes.txt) contains N rows and 2 columns (N is the number of spikes). The second column corresponds to the time stamps of the spiking activity and the first one to the corresponding electrode ID (numbered from 1 - top left of the recording matrix - to 4096 - bottom right of the recording matrix). Another file contains the time artifacts (filename_tart.txt). Finally the file “filename_stertstop.txt“ reports the start and stop times of the recording.
   Stimulation protocol:
   In all experiments, 8 of the available 16 stimulation electrodes were used (numbered 1 to 16 with the same top left to bottom right convention). A pseudorandom stimulation sequence was implemented according to protocols 1 and 2.
       protocol 1 (used for 208, 212, 214):
           stimulation electrodes {2,4,5,7,10,12,13,15} are activated repeating the sequence 
           [10,2,15,5,13,7,12,4,15,7,10,13,2,4,5,12] 16 times ( yielding a total of 32 repetitions per stimulus)
       protocol 2 (used for 331, 332):
           stimulation electrodes {1,3,6,8,9,11,14,16} are activated repeating the sequence
           [1,11,16,14,3,9,8,6,14,3,6,1,11,9, 8,16,6,11,14,9,8,16,1,3,14,8,6,1,11,9,3,16] 30 times
           (yielding a total of 60 repetitions per stimulus)
   Contributors:
   Thierry Nieus (IIT)
   Alessandro Maccione (IIT)
   Hayder Amin (IIT)
   Stefano Di Marco (IIT)
   Luca Berdondini (IIT)